

While the terms “complex CAD” or “high‐risk CAD” have not been formally defined, they encompass both complex anatomic lesions and clinical parameters including advanced age, frailty, comorbidities, compromised hemodynamic status, depressed ventricular function and concomitant valvular disease. Such features increase both the procedural complexity of percutaneous coronary intervention (PCI) and the risk of adverse patient outcomes. This statement aims to: