Apr 19th 2021

North American Societies Release Initial Findings from the North American Cardiovascular COVID-19 Myocardial Infarction Registry

Press Release Clinical Practice Congenital Coronary COVID-19 Diversity, Equity and Inclusion Peripheral Structural and Valvular

In a collaboration between three cardiology societies, initial findings from the North American Cardiovascular COVID-19 Myocardial Infarction (NACMI) Registry were published online in the Journal of the American College of Cardiology (JACC) today, the largest prospective ST-segment elevation myocardial infarction (STEMI) COVID registry of its kind.

WASHINGTON – In a collaboration between three cardiology societies, initial findings from the North American Cardiovascular COVID-19 Myocardial Infarction (NACMI) Registry were published online in the Journal of the American College of Cardiology (JACC) today, the largest prospective ST-segment elevation myocardial infarction (STEMI) COVID registry of its kind. The registry sought to define baseline characteristics and management strategies and outcome data for COVID+ patients presenting with STEMI. These results demonstrate COVID+ patients with STEMI are a high-risk population with unique demographic and clinical characteristics resulting in an increased risk of mortality and stroke.

Under the guidance of the American College of Cardiology Interventional Council, Canadian Association of Interventional Cardiology, and the Society for Cardiovascular Angiography & Interventions, the registry enrolled 1,185 patients presenting with ST segment elevation at 64 sites across the United States and Canada. Three groups of patients were included in the registry: 1.) COVID+ patients, 2.) suspected positive or person under investigation, and 3.) a matched control group from a large STEMI registry.

“Our findings indicate that Black and Hispanic COVID+ patients and those with diabetes mellitus more frequently presented with STEMI. “COVID+ patients with ST elevation have a very high in-hospital mortality rate of 33%,” said Santiago Garcia, MD of the Minneapolis Heart Institute Foundation and lead author of the study. “Fortunately, most patients received primary percutaneous coronary intervention (PPCI) with very small treatment delays (@ 15 min) despite the pandemic,” he continued. Many patients presented with respiratory symptoms rather than chest pain, and cardiogenic shock was common (18%), which likely contributes to the high fatality rate. The study also showed that 23% of patients had “no clear culprit” artery and may represent different reasons for ST-segment elevation including microthrombi, myocarditis, or takotsubo cardiomyopathy.

“This is the largest registry of COVID+ patients presenting with STEMI. These results clearly illustrate the challenges and uniqueness of this patient population that deserves prompt and special attention. The rapid development of this ongoing, critically important prospective registry reflects the strong and unique collaboration of all 3 societies. It was gratifying to be part of this process and hopefully the results will improve the care of our patients and stimulate further research,” stated Timothy Henry, MD, president-elect of SCAI and study chair.

For more information on the NACMI registry, please visit the SCAI COVID-19 Resource Center: https://scai.org/covid-19-resource-center.