SCAI Door to Lactate Clearance (SCAI DLC) Cardiogenic Shock Initiative: Definition, Hypothesis, and Call to Action | SCAI
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Sep 19th 2025 | Position Statement

SCAI Door to Lactate Clearance (SCAI DLC) Cardiogenic Shock Initiative: Definition, Hypothesis, and Call to Action

Cardiogenic Shock Mechanical Circulatory Support (MCS)

Please note, this document is an uncorrected proof. 

As cardiogenic shock (CS) care becomes increasingly complex—with various support devices, biomarkers, hemodynamic profiles, etiologies, and patient characteristics influencing outcomes—tissue perfusion has emerged as the most reliable early and ongoing indicator of survival. 

The SCAI SHOCK classification is designed for repeated use to monitor CS progression, with worsening stages clearly linked to poorer outcomes. Among potential markers, serum lactate stands out as a practical and responsive bedside test that reflects changes in perfusion and management. This document highlights lactate as a promising marker for tracking CS trajectory and calls for further research to validate its use.

All authors: Srihari S. Naidu, MD, MSCAI; Sandeep Nathan, MD, MSc, FSCAI; Mir B. Basir, DO; FSCAI; David A. Baran, MD, FSCAI; Jeffrey Marbach, MBBS, FSCAI; and Cindy L. Grines, MD, MSCAI. 

2026 SCAI SHOCK—Register Now!
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SCAI SHOCK: Home of the Shock Team is a step-by-step guide to building a contemporary cardiogenic shock program led by a multi-disciplinary team of seasoned leaders, each with a wealth of experience running and participating in cardiogenic shock programs.

 

This year's meeting will explore the individual building blocks of a contemporary shock program, equipping attendees with a comprehensive understanding of shock management, from initial recognition to advanced treatment strategies, and actionable insights you can take back to your institution.